NCT Number: NCT07047482
Evaluation of the immunohistochemical expression of p16 in colorectal carcinoma and correlate its expression to different clinical and pathological parameters as patients' ages, sexes, tumor location, histopathological phenotype, status of nodal involvement, perineural and lymphovascular invasion.
Interested in participating?
Request InfoAll sexes
Observational
Sohag, Recruiting, Egypt
Location status: Recruiting
Magdy M Amin, Professor
CONTACT
Sherry R Azmy, Demonstrator of pathology
CONTACT
01507557371 ext. 01507557371
Sherry R Azmy, Demonstrator of pathology
PRINCIPAL_INVESTIGATOR
Colorectal Carcinoma is very common nowadays, with increasing need for further research.
p16 is tumor suppressor gene with a vital rule ; inactivation of p16 leads to tumor formation and progression.
50 Specimens will be collected from Pathology Department of Sohag University Hospital. Sufficient clinical and histopathological data will be attached for each case.
The previously processed formalin-fixed, paraffin-embedded tissue blocks will be used to get Hematoxylin & Eosin stained sections to confirm the diagnosis and to detect the histopathological type, grade and stage of each tumor.
Another sliced tissue sections will be immunohistochemically stained with p16 monoclonal antibodies to be evaluated with the positivity, intensity and distribution of the detected stain.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Immunohistochemical staining of paraffin embedded blocks of colorectal carcinoma tissues by p16 monoclonal antibodies to be evaluated with the positivity, intensity and distribution of the detected stain.
Time frame: 6 months
Immunohistochemical staining of Colorectal tissues by p16 monoclonal antibody
Time frame: 6 months
Correlation of p16 expression to different clinical and pathological parameters as patients' ages, sexes, tumor location, histopathological phenotype, status of nodal involvement, perineural and lymphovascular invasion.
Contact information is provided by the study sponsor or research team.
Sohag University
Other
Clinicopathological Value of p16 Expression in Colorectal Carcinoma: An Immunohistochemical Study.
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