Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia)

Inclusion criteria

• Age > 60 years old
• Patient diagnosed with dementia confirmed by psychiatrist or neurologist based on DSM-4 or ICD 10
• Patient with Mini-Mental State Examination (MMSE) between 10 to 20 indicating moderate cognitive impairment
• Patient is in stable condition without life threatening disease or uncontrolled medical condition
• Patient undergoing stable dose treatment for other medical condition at least 4 months before the trial
• Patient with care giver or supporting family who can assist patient with research protocol

Exclusion criteria

• Patient has dementia due to other medical condition such as severe head trauma, brain infection or history of drug abuse
• Patient with uncontrolled medical condition such as severe cardiovascular disease, chronic lung disease, cancer, or systemic infection
• Patient with severe psychiatry disorder such as schizophrenia and bipolar disorder
• Patient is receiving experimental drugs or participates in experimental studies for the last 30 days before the trial
• Patient who has allergy or hypersensitivity reaction towards secretome
• Patient with medical complications or surgery complications that require immediate interventions or other life threatening complications
• Patient is unable to provide written informed consent and not capable to understand and comply to research protocol
• Patient is unwilling and not capable to follow research protocol including follow up evaluations and blood sampling according to schedule