Skip to main content
OpenTrials
Completed

NCT Number: NCT00241072

Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance

THE PURPOSE OF THIS STUDY IS TO DETERMINE IF 24 WEEKS OF TREATMENT WITH VALSARTAN (80 MG - 320 MG) IMPROVES INSULIN SENSITIVITY IN SUBJECTS WITH HIGHER THAN NORMAL GLUCOSE LEVELS USING A TEST CALLED THE EUGLYCEMIC CLAMP.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypertension Cardiovascular Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Impaired Glucose Tolerance Metabolic Diseases Nutritional and Metabolic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

history or presenting hypertension Elevated fasting blood glucose levels -

Exclusion criteria

Pregnancy potential Diabetes mellitus

Other criteria apply

-

Treatment and study plan

valsartan

Drug

24 WEEKS OF TREATMENT WITH VALSARTAN (80 MG - 320 MG)

Primary outcomes

  1. Change from baseline insulin sensitivity after 24 weeks

Secondary outcomes

  1. Change from baseline in the function of cells that line blood vessels after 24 weeks

  2. Change from baseline in markers of vascular inflammation after 24 weeks

  3. Adverse events and serious adverse events at each study visit for 24 weeks

  4. Hematology, blood chemistries, and urine measurements for up to 24 weeks

  5. Vital signs and physical examinations for up to 24 weeks

Sponsors and collaborators

Lead sponsor

Novartis

Industry

Registry information

Official study title

A Single Center, Open Label, Single Arm Trial To Evaluate The Effect Of Twenty Four Weeks Of Treatment With 80 Mg To 320 Mg Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance (Igt)

Important dates

Study start
2002
Primary completion
2005
Study completion
2005
First posted
Oct 18, 2005
Registry last updated
May 4, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.