Clinical Trial of Metal-Reinforced Teeth Designed for Endoscopic Clips

With the advancement of endoscopic technology, gastrointestinal defects following endoscopic submucosal dissection (ESD), mucosal resection (EMR), and full-thickness resection (EFTR), as well as complications such as gastrointestinal bleeding, diverticula, fistulas, perforations, and even fixation of esophageal stents, can gradually be treated through endoscopic procedures. This approach avoids surgical incisions and reduces patient recovery time. Traditional endoscopic hemoclips have limited application due to constraints such as arm extension distance, size of the clip's front teeth, and closing force. Therefore, the investigators have developed metal-reinforced teeth for hemoclips. This initial clinical study aims to validate the safety, feasibility, and effectiveness of reinforced teeth in clinical applications. The investigators also aim to explore the uses and limitations of this technology. The primary outcome measures include technical success rate and clinical success rate. Additionally, the investigators closely monitor procedure time, the number of clip uses during the procedure, and postoperative adverse events during follow-ups.

Inclusion criteria

• 1. Gastrointestinal lesions that require clips include non-variceal upper gastrointestinal bleeding, post-endoscopic submucosal dissection (ESD) lesions in the gastrointestinal tract, fistulas, diverticula, perforations, and anchoring of self-expanding metal stents.
• 2. Expected survival greater than 30 days;
• 3. Written informed consent.

Exclusion criteria

• 1. Patients with diffuse gastrointestinal lesions, such as Crohn's disease and ulcerative colitis;
• 2. Patients who clearly require surgical intervention;
• 3. Serious cardio-pulmonary, hepatic or renal disease;
• 4. Intolerance to endoscopy;
• 5. Pregnant or lactating women.