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Completed

NCT Number: NCT02152865

Clinical Trial of Lupeol for Mild-moderate Acne

For the chemical lupeol isolated from eggplant, we applied it to one side of face, and applied vehicle control to another side for 8 -weeks. The study was performed in a 8-week, randomized controlled, split face fashion. Investigators evaluated safety and efficacy during baseline, 2 weeks, 4weeks, and 8 weeks after beginning of study.

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Key information

Conditions

Acne Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

15 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over the age 15 who were clinically diagnosed with mild to moderate acne vulgaris

Exclusion criteria

  • ; known pregnancy or lactation, any medical illness that might influence the results of the study, a previous history of oral acne medication or surgical procedures including laser treatment within 6 month and topical medication within 4 weeks of study enrollment.

Treatment and study plan

Lupeol

Drug

Patients are supposed to apply lupeol cream to one side of their face two times per day for 8 weeks.

Other names: no brand name

Control vehicle

Drug

Patients are supposed to apply their control vehicle to the other side of their face for 8 weeks

Other names: No brand name

Primary outcomes

  1. Acne lesion counts as a measure of efficacy

    Time frame: 8 weeks after beginning of applications

    Both inflammatory & non-inflammatory acne lesions of both of their facial sides

Secondary outcomes

  1. Number of Participants with Adverse Events as a Measure of Safety and Tolerability

    Time frame: 8 weeks after beggning of applications

    Among total patients enrolled in this study, number of patients either experiencing objective adverse events or subjective uncomfortableness were counted

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2009
Primary completion
2014
Study completion
2014
First posted
Jun 2, 2014
Registry last updated
Jun 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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