Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy

Inclusion criteria

• Male or female infants or children 16 years of age or younger
• Patient must be a suitable candidate for conventional 2-port or 3-port pars plana vitrectomy
• Patient with attached vitreous somewhere in posterior pole
• Patient's parent or guardian must be willing and able to comply with follow-up requirements
• Patient's parent(s) must sign informed parental permission form and in the case of school-age children the patient must sign assent form

Exclusion criteria

• Patient diagnosed with Stage 1, 2, 3 or 5 retinopathy of prematurity (ROP) at the time of surgery
• Unclear media, which precludes assessment of the posterior pole such as a cataract or vitreal opacity
• Active parental/guardian drug or alcohol use or dependence that, in the opinion of the site Investigator, would interfere with parent's or guardian's adherence to study requirements
• Medical problems that make consistent follow-up over the treatment period uncertain.
• Patient must not have participated in an investigational drug or device study in the prior 30 days
• Female Patients of childbearing potential must not be pregnant or lactating.