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NCT Number: NCT07308015

Clinical Study on the Treatment of Rhinitis Sicca With Sodium Hyaluronate Adjustable Nasal Irrigator

To observe the therapeutic effect of sodium hyaluronate adjustable nasal irrigator on various types of rhinitis sicca and compare it with the therapeutic effect of the commonly used physiological seawater nasal spray in clinical practice.

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Key information

Conditions

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

China-Japan Union Hospital of Jilin University

Changchun, Jilin, 130000, China

Location status: Recruiting

Location contact

Liwei Sun, Doctor

CONTACT

[email protected]

86+18243189793

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Symptoms: Dry nose sensation, little and thick nasal discharge, nosebleeds, itchy nasal cavity, and dryness in the nasopharynx. Physical signs: Nasal endoscopy often reveals dry and congested nasal mucosa, which appears grayish-white or dark red, losing its normal luster. There are often dry, thick secretions, scabs or blood scabs on it. The surface of the nasal mucosa is eroded and ulcers occur. The mucosal lesions are most obvious in the anterior part of the nasal cavity. A diagnosis can be made if one or more of the above symptoms and signs are present.

Exclusion criteria

  • Those with dry rhinitis and chronic inflammation of the lower respiratory tract.
  • Those confirmed by examination to be caused by certain latent lesions in the mouth, nose, throat, esophagu.s, neck or the whole body
  • Those who have used drugs for treating dry rhinitis or other medications within the past 30 days.
  • Pregnant or lactating women.
  • Those who are allergic to this medicine.
  • Those with severe cardiovascular, liver, kidney and hematopoietic system diseases, etc.
  • Mentally ill patients.

Treatment and study plan

Physiological seawater adjustable nasal irrigator

Drug

Nasal spray of Physiological seawater.

Sodium hyaluronate adjustable nasal irrigator

Drug

Nasal spray of Sodium hyaluronate

Primary outcomes

  1. Visual Analogue Scale (VAS)

    Time frame: Two weeks after the treatment

Secondary outcomes

  1. Nasal endoscopy examination score

    Time frame: Two weeks after the treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Cuida Meng, Doctor

CONTACT

[email protected]

86+13596096000

Sponsors and collaborators

Lead sponsor

China-Japan Union Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 29, 2025
Registry last updated
Dec 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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