Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

Primary aim: estimate the effect, in terms of clinical response, of carbon ion treatment (CIRT) in patients with lateral pelvic recurrences of gynecological malignancies.

Secondary aims:

• To describe the safety profile of carbon ion therapy.
• To estimate the effect, in terms of survival, of carbon ion treatment

Inclusion criteria

• Patients ≥ 18 years of age
• Karnofsky Index ≥ 70
• Histological or radiological diagnosis of pelvic and groin recurrence
• Contraindications for radical surgery
• No other distant progression or stable disease (SD) of known secondarisms (≥6 months)
• Previous radiation therapy on pelvis
• Distance ≥ 10mm between tumour and close intestinal tract (small intestine), radiologically evaluated
• Possibility to perform a surgery to space the intestinal loops, in case of distance < 10mm
• If needed, spacer in biocompatible material (silicon, goretex) or anatomical material (omentum, muscle patch), non-absorbable.
• DICOM (Digital Imaging and COmmunications in Medicine) images of the previous treatment plan availability
• Written informed consent
• Patient's ability to understand the characteristics and consequences of the clinical trial

Exclusion criteria

• Hip prosthesis, metal prostheses or any other condition that prevents adequate imaging to identify the target volume and calculate the dose in the treatment plan

• Intestinal infiltration
• Bladder infiltration
• Vessel infiltration
• Previous therapy with anti-angiogenesis drugs
• Psychic or other disorders that may prevent informed consent
• Previous invasive tumor, with the exception of skin cancer (excluding melanoma) unless disease-free for at least 3 years
• Spacer in absorbable material (i.e. vycril)
• Distance < 10mm between tumour and close intestinal tract (small intestine), radiologically evaluated
• Impossibility to assess MRI