Clinical Study for P-MAR

The purpose of this clinical study is to evaluate the performance of the P-MAR metal artifact reduction algorithm for CT imaging (with metal present) of adult patients (>18 years old).

The study has two objectives:

1. To evaluate the extent of metal artifacts and diagnostic confidence, and overall image quality (independent of metal artifacts) of P-MAR compared to images without metal correction, and compared to O-MAR, for CT images (with metal present) of adult patients (>18 years old). 2. To demonstrate non-inferiority of P-MAR compared to images without metal correction for the relevant metal groups.

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Key information

Conditions

Computed Tomography

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects scanned by FDA-cleared and marketed Philips Incisive CT or CT 5300 systems, and according to the department standard of care clinical protocols.
Subject age: Above 18 years old.
Scans with metal present (orthopedic implants/joint prothesis, dental filling/implants, spine screw(s), pacemaker, coils, radiotherapy beads, surgical clips/staples, metal objects either outside the body or near air, etc.)

Exclusion criteria

Subject age: 18 years old and below.
CT scans with no metal present.
CT scans with metal with motion artifacts.
Surview or Locator/Tracker.
CT scans performed utilizing respiratory gating (e.g., "pulmo gating").
CT scans performed utilizing cardiac gating.
CT Perfusion scans.
CCT scans.
Scans that the site radiologists have deemed as non-diagnostic image quality in standard practice (e.g. patient movement).
Scans that are not completed due to technical difficulties.

Treatment and study plan

Primary outcomes

The extent of metal artifacts and diagnostic confidence of P-MAR

Time frame: Reading session at 4 months

The extent of metal artifacts and diagnostic confidence of P-MAR reconstructions is at least as good as (non-inferior to) images without metal correction, for CT images (with metal present) of adult patients (>18 years old).

Sponsors and collaborators

Lead sponsor

Philips Clinical & Medical Affairs Global

Industry

Collaborators

Philips Healthcare (Suzhou) Co., Ltd.

Registry information

Official study title

Clinical Study for P-MAR Metal Artifact Reduction Algorithm for Incisive CT and CT 5300 Systems

Acronym: Precise MAR

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jan 5, 2026
Registry last updated: Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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