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OpenTrials
Completed

NCT Number: NCT01753505

Clinical Significance of 64-slice Multidetector Coronary CT Angiography to Evaluate the Prevalence and Severity of Coronary Artery Disease in Renal Transplant Recipients

The aim of this study is to evaluate the clinical usefulness of 64-slice multidetector coronary CT angiography (MDCTA) in renal transplant recipients who had no previous coronary artery disease (CAD). Primary endpoint is to assess the prevalence and severity of coronary artery disease in patients post-transplant 6 to 12 months. CAD can be diagnosed noninvasively with similar accuracy of coronary angiography using MDCTA. Early detection and intervention of CAD may provide survival benefit in renal transplant recipients.

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Key information

Conditions

Kidney Transplant Recipient

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Severance hospital

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥ 40 yrs
  • renal transplant recipient at post-transplant 6 to 12 months
  • stable graft renal function: CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation ≥45 mL/min/1.75m2
  • patients who had no previous CAD

Exclusion criteria

  • unstable graft renal function
  • History of acute kidney injury within 3 months
  • Allergic history to contrast agent
  • Irregular heart beat
  • Multiorgan transplant recipients
  • Pregnancy
  • Patients who do not consent to this study

Treatment and study plan

64-slice Multidetector coronary CT angiography

Other

Primary outcomes

  1. prevalence of coronary artery disease

    Time frame: at post-transplant 6 to 12 months.

Secondary outcomes

  1. severity of coronary artery disease

    Time frame: at post-transplant 6 to 12 months

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Dec 20, 2012
Registry last updated
Nov 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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