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Completed

NCT Number: NCT04126577

Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis

When there is infection in the intra-abdominal area, bacteria secrete toxins that are absorbed by the peritoneum. These toxins then bind to lipoproteins (which carry cholesterol in the blood) and are eliminated by the liver. Phospholipid transfer protein (PLTP) is a protein that facilitates the binding of bacterial toxins to lipoproteins and thus their elimination.

The objective of this study is to study the relationship between PLTP and the elimination of bacterial toxins in humans. A better understanding of the elimination of these toxins will lead to a better understanding of the disease. The ultimate objective is to improve the management of intra-abdominal infections.

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Key information

Conditions

Peritonitis Digestive System Diseases Infections Intraabdominal Infections Peritoneal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Dijon Bourogne

Dijon, 21000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • person who has given oral consent (patient or family member)
  • pre-operative SEPSIS criteria (qSOFA >=2) or vasopressor or mechanical ventilation treatment
  • admitted to the operating room for suspected generalized secondary peritonitis

Exclusion criteria

  • person not affiliated to national health insurance
  • person under legal protection (curatorship, guardianship)
  • person under court order
  • pregnant, parturient or breastfeeding woman
  • minor
  • immunosuppression (HIV infection, corticosteroid treatment > 0.15 mg/kg/day prednisolone equivalent > 2 weeks, immunosuppressive treatment, primary cellular immune deficiency)
  • decision to limit or stop therapy

Treatment and study plan

blood samples

Biological

4 blood samples of 6 ml each: one before the surgical incision, one after the operation, one 4h after the operation and the last 24h after the operation.

Primary outcomes

  1. Perioperative plasma concentration in 3HM

    Time frame: 24 hours postoperatively

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Official study title

Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis An Observational Prospective Study

Acronym: LIPS

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Oct 15, 2019
Registry last updated
Aug 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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