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Completed

NCT Number: NCT05113667

Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

To evaluate the impact of clinical pharmacist-led appropriate acid suppression therapy stewardship program in hospitalized older patients.

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Key information

Conditions

Geriatric

Age range

65 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Marmara University

Istanbul, Turkey (Türkiye)

About this study

This prospective, nonrandomized controlled study was conducted in older patients who ordered proton pump inhibitor (PPI) at admission in an internal medicine service of tertiary training and research hospital. In the intervention group, clinical pharmacist-led services (including medication reconciliation and medication review) were conducted during hospitalization and at discharge by using the guidelines and potentially inappropriate medications (PIM) criteria [American Geriatric Society-AGS Beers Criteria©, 2019]. Medication Appropriateness Index (MAI), inappropriate PPI cost, and hospitalization for gastrointestinal bleeding within 1 year after discharge were calculated in both groups

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 65 years old or greater
  • Admitted to the hospital with any reason
  • Ordered at least one PPI dose within 48 hours of admission

Exclusion criteria

  • Transferred to another ward (including an intensive care unit)
  • Having active gastrointestinal bleeding
  • Having active malignity

Treatment and study plan

Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

Other

Clinical pharmacist provided medication reconciliation and medication review during the hospital stay.

Primary outcomes

  1. Appropriateness of Proton Pump Inhibitors Usage

    Time frame: during hospital stay, an average of 14 days

    The rate of appropriateness use of proton pump inhibitors based on the guidelines at hospital stay

  2. Potentially Inappropriate Proton Pump Inhibitors Usage

    Time frame: at discharge, an average of 14 days after admission to hospital

    The rate of potentially inappropriate use of proton pump inhibitors based on American Geriatric Society Beers Criteria© 2019

Secondary outcomes

  1. Clinical outcome

    Time frame: 1 year

    The number of patients who hospitalized for bleeding within 1 year after discharge

  2. Cost saving during hospital stay

    Time frame: during hospital stay, an average of 14 days

    Medication cost for inappropriate PPI during hospital study

  3. Medication Appropriateness Index for Proton Pump Inhibitors at hospital stay

    Time frame: during hospital stay, an average of 14 days

    Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.

    Higher scores of this index represent more inappropriateness of each medication.

  4. Cost saving after discharge

    Time frame: a month

    Medication cost for potentially inappropriate PPI after discharge

  5. Medication Appropriateness Index for Proton Pump Inhibitors at discharge

    Time frame: at discharge, an average of 14 days after admission to hospital

    Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.

    Higher scores of this index represent more inappropriateness of each medication.

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Official study title

Impact of Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program on Hospitalized Older Patients: A Non-Randomized Controlled Study

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
Nov 9, 2021
Registry last updated
Oct 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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