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NCT Number: NCT07524842

Clinical Performance of Three Different Restorative Materials

The clinical performance of a bioactive composite (alkasite-based), a nanohybrid resin composite and a bulk-fill resin composite in class II restorations will be evaluated and compared. After recruiting participants with at least 3 approximal caries lesions, all restorations will be placed by a single clinician. All caries lesions will be removed before restoring. Cavities will be divided into three groups: a bioactive composite [Cention Forte Ivoclar Vivadent, Schaan, Liechtenstein], a nanohybrid resin composite [Tetric N-Ceram2 (Ivoclar Vivadent, Schaan, Liechtenstein)] and a bulk-fill resin composite [Tetric N-PowerFill2 (Ivoclar Vivadent, Schaan, Liechtenstein)], All restorative procedures will be conducted according to manufacturers' instructions. Restorations will be scored using FDI criteria after a week (baseline) 6, 12, 24, 36 and 48 months. Descriptive statistics will be performed using chi-square tests.

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Key information

Conditions

Tooth Disease Stomatognathic Diseases Tooth Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age range will be 18 to 65
  • patients should have at least 3 approximal caries lesions require restoration
  • healthy periodontal status
  • a good likelihood of recall availability

Exclusion criteria

  • poor gingival health
  • adverse medical history
  • potential behavioral problems

Treatment and study plan

bioactive composite

Device

bioactive composite restoration

nanohybrid resin composite

Device

nanohybrid resin composite restoration

bulk-fill resin composite

Device

bulk-fill resin composite restoration

Primary outcomes

  1. Clinical performances of different restorative systems according to FDI criteria

    Time frame: two years

    Two year results according to FDI criteria (scores 1-5, 1-very good, 5-poor/replace)

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Clinical Performance of Three Different Restorative Materials-Nanohybrid, Bulk-fill, and Alkasite-based

Important dates

Study start
2026
Primary completion
2026
Study completion
2028
First posted
Apr 13, 2026
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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