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Active, Not Recruiting

NCT Number: NCT07688343

Clinical Performance of Different Ion-Releasing Restorative Systems in Class II Cavities

Different ion-releasing restorative systems will be applied in class II cavities then their clinical performance will be evaluated and compared

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Dental Caries Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Mansoura University

Al Mansurah, Dakahlia Governorate, 35516, Egypt

About this study

This randomized clinical trial aims to evaluate the clinical performance of different ion-releasing restorative systems used in Class II posterior cavities over a two-year follow-up. Patients must be in adults (not less than 18 years old), able to attend regular follow-up visits, presenting with at least four carious class II posterior teeth requiring restoration. Pregnant patients will be excluded.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 4 carious posterior teeth

Exclusion criteria

  • pregnancy - not able to attend for regular follow-up -smokers or very bad oral hygiene

Treatment and study plan

conventional bulk fill restorative system

Procedure

conventional bulk fill restorative system used for posterior applications

ion-releasing restorative system 1

Procedure

ion-releasing restorative system 1 used for posterior applications

ion-releasing restorative system 2

Procedure

ion-releasing restorative system 2 used for posterior applications

ion-releasing restorative system 3

Procedure

ion-releasing restorative system 3 used for posterior applications

Primary outcomes

  1. difference between baseline and after two years of evaluation

    Time frame: baseline to two-years

    Changes in restoration performance according to the modified Federation Dentaire Internationale (FDI) criteria from baseline to 2 years. Scores range from 1 to 5, where lower scores indicate better clinical performance and higher scores indicate poorer clinical performance.

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Two-Year Clinical Performance of Different Ion-Releasing Restorative Systems Applied in Class II Cavities

Acronym: ION-REST II

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 7, 2026
Registry last updated
Jul 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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