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NCT Number: NCT05283603

Clinical Observational Registry of Patients With Left Bundle Branch Block

The electromechanical dyssynchrony induced by the presence of LBBB is in some patients, but not all, the cause of progressive left ventricular systolic dysfunction and heart failure.

Aims

1. To investigate the clinical, ECG, imaging-derived features in a large cohort of patients affected by LBBB on ECG. 2. To identify predictors of LBBB-induced LV systolic dysfunction and predictors of outcome in this population. 3. To derive data which may have an impact on therapeutic management.

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Key information

Conditions

Left Bundle Branch Block (LBBB) on ECG Arrhythmias, Cardiac Bundle-Branch Block Cardiac Conduction System Disease Cardiovascular Diseases Heart Block Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiology, AOU Sassari

Sassari, 07100, Italy

Location status: Recruiting

Location contact

Giuseppe D Sanna, MD PhD

CONTACT

[email protected]

0039 2061561

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • LBBB on ECG

Exclusion criteria

  • Previous extensive anterior myocardial infarction
  • Previous cardiac surgery or transcatheter aortic valve implantation (TAVI)
  • Congenital structural heart disease
  • Patients implanted with permanent right ventricular stimulation devices and permanent pacing
  • Denial to consent

Treatment and study plan

ECG, Echocardiogram, Magnetic resonance

Diagnostic Test

Clinical and instrumental follow-up

Primary outcomes

  1. Left ventricular dysfunction

    Time frame: 20 years

    Echocardiographic left ventricular ejection fraction - EF (%)

Secondary outcomes

  1. Adverse cardiovascular events (e.g., heart failure)

    Time frame: 20 years

    Heart failure (incidence and prevalence) Hospitalizations due to heart failure MACE

Study contacts

Contact information is provided by the study sponsor or research team.

Giuseppe D Sanna, MD PhD

CONTACT

[email protected]

+39 0792061561

Giuseppe D Sanna, MD PhD

CONTACT

+39 0792061561

Sponsors and collaborators

Lead sponsor

Azienda Ospedaliero Universitaria di Sassari

Other

Registry information

Official study title

Registro Osservazionale Dei Pazienti Con Blocco Della Branca Sinistra

Acronym: RECOrd-LBBB

Important dates

Study start
2019
Primary completion
2021
Study completion
2029
First posted
Mar 17, 2022
Registry last updated
Mar 17, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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