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Completed

NCT Number: NCT02199522

Clinical Observation of Titration Induction and Convention Induction of Propofol

As we know propofol is popular use in the anesthesia induction with kilogram and it always cause hypotension. So we compare haemodynamic changes and drug consumption between propofol titrated administration and traditional administration for anesthesia induction.

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Key information

Conditions

Propofol Overdose of Undetermined Intent

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesia ,Sixth Affiliated hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510655, China

About this study

GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min, GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to 1, then changed to a maintenance dose

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with American Society of Anesthesiologists(ASA)Ⅰor Ⅱ and aged 18-60 yr, who were scheduled for general anesthesia.

Exclusion criteria

  • Hypertension, Severe heart,pulmonary,brain，liver and renal dysfunction; excess obesity , predicted difficult intubation,hearing obstacles;. Allergic to propofol or its fat emulsion;addictive to sedative and other drugs.

Treatment and study plan

titration induction to propofol

Procedure

propofol intravenously by Fresenius pump at the speed of 1 mg•kg-1•min-1, and OAA/S scale of the patients was titrated to 1

Primary outcomes

  1. systolic pressure diastolic pressure mean blood pressure

    Time frame: 15minutes

    before propofol dosage ,1 min after the propofol dosage, 3 min , 5 min

    , endotracheal intubation done immediately,1 min,3 min,5 min,7 min,9 min after endotracheal intubation

Secondary outcomes

  1. total dosage of propofol using

    Time frame: 15 minutes

Sponsors and collaborators

Lead sponsor

Lihong Chen

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jul 24, 2014
Registry last updated
Oct 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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