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Completed

NCT Number: NCT01154946

Clinical Implication of DAC (Detrusor After-contraction)

The aims of this study are

* to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach * and to understand clinical implication of DAC

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Key information

Conditions

Voiding Dysfunction Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Lower Urinary Tract Symptoms Male Urogenital Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Urinary Bladder Diseases Urinary Bladder, Overactive Urogenital Diseases Urologic Diseases Urological Manifestations

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

About this study

The definition of detrusor after-contraction (DAC) is usually accepted as the increase of detrusor pressure (Pdet), whether it is sudden or not, after cessation of urinary flow. The amount of increase in Pdet is sometimes included in the definition of DAC (14, 15, 20 cmH2O or at least two times the level of the maximal Pdet during the voiding phase). However, it is clear that the lack of a well-established definition may induce much bias in the interpretation of the clinical implication of DAC. The previous studies showed a wide range of prevalence.1-4 DAC seemed to occur more frequently in children and the occurrence rate usually decreased with age in urodynamic studies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Indications and selection of patients for conduction of urodynamic studies (UDS) were followed as the recommendation of ICS (international continence society).

Exclusion criteria

  • Patients with indwelling catheters, urinary tract infection and urinary stones were excluded from this study

Treatment and study plan

Primary outcomes

  1. to confirm whether DAC is a true contraction or not

    Time frame: up to 2 years (2007.Jan-2008.Dec)

    no change of Pdet when patients cough could confirm that DAC was a true contraction. Because an artifact occurred when a catheter was pressed against bladder wall or urethra, no change of intravesical pressure and increase of abdominal pressure finally induced a negative deflection of Pdet and this change of Pdet could be regarded as an artifact.

Secondary outcomes

  1. Past medical history including neurological disorders and pelvic irradiation were also included in the database

    Time frame: up to 2 years (2007.Jan-2008.Dec)

    One-way analysis of variance and the chi-square test were performed to determine whether there was a relationship between the presence of DAC and the underlying neurogenic and non-neurogenic conditions

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

A New Approach to Clinical Implication of Detrusor After-contraction (DAC)

Acronym: DAC

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Jul 1, 2010
Registry last updated
Jul 1, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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