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NCT Number: NCT04794595

Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children

The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

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Key information

Conditions

Sepsis Children, Only Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

28 day–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Children'S Hospital of Fudan University

Shanghai, Shanghai Municipality, 201102, China

Location status: Recruiting

Location contact

YING JIAYUN

CONTACT

[email protected]

18817583962

About this study

Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age of 29d to 18 years old;
  • Children diagnosed with sepsis requiring blood purification.

Exclusion criteria

  • with a history of a duration of PICU stay <24 h
  • active bleeding, including cerebral hemorrhage

Treatment and study plan

CBP

Procedure

continuous blood purification can prevent or treat fluid overload in children with septic shock or other sepsis-associated organ dysfunction who are unresponsive to fluid restriction and diuretic therapy management of septic AKI patients, particularly those with hemodynamic instability or fluid overload. Also, it can remove cytokines

Other names: traditional therapy

Primary outcomes

  1. survival rate

    Time frame: 28 days after hospital discharge

    The survival rate of children in 28 days after hospital discharge

Secondary outcomes

  1. The creatinine level of non-survival children with sepsis

    Time frame: 28 days after hospital discharge

    The creatinine level of non-survival children with sepsis in 28 days after hospital discharge

Study contacts

Contact information is provided by the study sponsor or research team.

YING JIAYUN

CONTACT

[email protected]

18817583962

Sponsors and collaborators

Lead sponsor

Children's Hospital of Fudan University

Other

Collaborators

  • Shanghai Children's Hospital
  • Shanghai Children's Medical Center
  • Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Registry information

Official study title

Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Mar 12, 2021
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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