Skip to main content
OpenTrials
Completed

NCT Number: NCT07395843

Clinical Feasibility of Full Free-Breathing Cardiac Magnetic Resonance Imaging

To evaluate the feasibility, efficiency, and diagnostic concordance of a full comprehensive free-breathing cardiac magnetic resonance protocol with motion correction and sensing.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

FAST Scan

Sex eligibility

All sexes

Study type

Observational

Primary location

Fuwai Hospital

Beijing, China

About this study

This study aims to establish a large-scale, clinically oriented full free-breathing cardiac MRI framework to eliminate dependence on patient breath-holding, substantially shorten scan time, and improve patient comfort. Building on prior successful implementation of compressed sensing and motion correction techniques, the invesitgators will collaborate with the MRI vendor and sequence scientists to develop a comprehensive set of free-breathing sequences, including cine imaging, T1/T2 mapping, flow, perfusion, and late gadolinium enhancement (LGE). The study will then prospectively enroll a large, disease-diverse cohort of cardiovascular patients at Fuwai Hospital and systematically compare the full free-breathing protocol with conventional breath-hold protocols in terms of acquisition time, image quality, and agreement of quantitative parameters, thereby providing a comprehensive assessment of technical feasibility and clinical value.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consecutive enrollment of patients referred for clinically indicated contrast-enhanced CMR

Exclusion criteria

  • patients with CMR contraindications

Treatment and study plan

Free-breathing CMR

Diagnostic Test

scan patients under free-breathing status

Primary outcomes

  1. scan time

    Time frame: Measurements are performed within 7 days after the completion of the CMR scan.

    total CMR examination time from the scanning time of first image to the last image

Secondary outcomes

  1. image quality

    Time frame: Measurements are performed within 7 days after the completion of the CMR scan.

    5-point Likert scale will be applied to assess image quality between two scanning methods, with a score of ≥3 considered clinically acceptable. Image quality was assessed visually using a 5-point Likert scale, defined as follows: 5 = excellent image quality; 4 = good quality with mild motion artifacts or distortion; 3 = presence of motion artifacts or distortion but sufficient image quality; 2 = fair quality with significant motion artifacts or distortion, limiting diagnostic utility; and 1 = non-diagnostic quality.

  2. consistence of left ventricular ejection fraction

    Time frame: Measurements are performed within 7 days after the completion of the CMR scan.

    Linear regression and Bland-Altman analyses will be used to assess the correlation and agreement of left ventricular ejection fraction (%) from different techniques.

  3. consistence of native T1 values

    Time frame: Measurements are performed within 7 days after the completion of the CMR scan.

    Linear regression and Bland-Altman analyses will be used to assess the correlation and agreement of native T1 values (ms) from different techniques.

Sponsors and collaborators

Lead sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Other

Registry information

Official study title

Full Free-Breathing Cardiac Magnetic Resonance Imaging: Clinical Feasibility, Efficiency, and Diagnostic Concordance

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 9, 2026
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.