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NCT Number: NCT06986525

Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions

This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.

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Key information

Conditions

Gingival Recession Gingival Diseases Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pamukkale University, Faculty of Dentistry, Periodontology

Denizli, 20160, Turkey (Türkiye)

Location contact

Gizem TORUMTAY CİN

PRINCIPAL_INVESTIGATOR

Necati Zavrak

CONTACT

[email protected]

+905367400103

About this study

The objective of this prospective clinical trial is to compare two mucogingival surgical techniques-coronally advanced flap (CAF) and tunnel technique-used in combination with platelet-rich fibrin (PRF) for treating multiple Miller Class I-II gingival recessions. Eleven systemically healthy participants with bilateral gingival recessions will be enrolled. CAF+PRF will be applied on one side, and Tunnel+PRF on the contralateral side. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level, recession height and width, and keratinized tissue height will be recorded at baseline, 3 months, and 6 months. Root coverage outcomes and clinical attachment gain will be analyzed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Systemically healthy individuals
  • Presence of bilateral Miller Class I-II multiple gingival recessions
  • Good oral hygiene and willingness to follow instructions
  • Signed informed consent

Exclusion criteria

  • Use of tobacco or smoking
  • Pregnancy or lactation
  • Presence of systemic diseases affecting periodontal health
  • Use of medications that may affect healing (e.g., corticosteroids)
  • Periodontal surgery in the same area within the last 6 months

Treatment and study plan

CAF with PRF

Procedure

Coronally advanced flap technique will be performed to reposition the gingival margin coronally. Platelet-rich fibrin (PRF) membranes will be placed over the exposed root surfaces and stabilized with sutures.

Tunnel with PRF

Procedure

A tunnel or subgingival pouch will be created using microsurgical instruments without vertical incisions. Platelet-rich fibrin (PRF) membranes will be inserted into the tunnel and the gingival tissue will be advanced coronally and sutured to cover the recession.

Primary outcomes

  1. Change in Recession Height (RH)

    Time frame: Baseline and 6 Months

    Recession height will be measured in millimeters from the cementoenamel junction to the gingival margin using a periodontal probe at baseline and 6 months postoperatively.

Secondary outcomes

  1. Change in Clinical Attachment Level (CAL)

    Time frame: Baseline, 3 Months, and 6 Months

    Clinical attachment level will be measured in millimeters using a periodontal probe to assess periodontal healing at different time points.

Study contacts

Contact information is provided by the study sponsor or research team.

Gizem Torumtay Cin, Assoc. Prof. Dr.

CONTACT

[email protected]

+905053913915

Necati Zavrak, RA

CONTACT

[email protected]

+905367401003

Sponsors and collaborators

Lead sponsor

Pamukkale University

Other

Registry information

Official study title

A Prospective Split-Mouth Clinical Study Comparing Coronally Advanced Flap and Tunnel Techniques Combined With Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 23, 2025
Registry last updated
Aug 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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