Clinical Efficacy of the Neoadjuvant Chemotherapy for IB2 and IIA2 Stage Cervical Cancer Patients

Inclusion criteria

• clinical diagnosis IB2 or IIA2 stage cervical cancer;
• age less than or equal to 65 years old;
• laboratory examination results: WBC ≥ 4*10^9/L, NEU ≥ 20*10^9/L, PLT ≥ 80*10^9/L, serum bilirubin ≤ 2 multiples of the upper normal limit, aminopherase ≤ 2 multiples of the upper normal limit. BUN ≤ normal limit, CR ≤ normal limit;
• KARNOFSKY score ≥ 60;
• No prior treatment;
• pathological diagnosis before surgery is invasive squamous cell carcinoma of cervix;
• well-compliance and willing to keep in touch;
• willing to participate in this study, and sign the informed consent;

Exclusion criteria

• participate in other drug clinical trials at the same time;
• respiratory depression, airway obstruction and hypoxia;
• heart diseases (cardiac function at grade II, III or above);
• hematological diseases;
• obvious dysfunction of liver and kidney (above 3 multiples of the upper normal limit);
• a history of brain dysfunction;
• unable to receive surgery and/or unsuitable for radiotherapy or chemotherapy;
• drug abuse or a history of drug abuse;
• unable or unwilling to sign informed consents;
• unable or unwilling to follow the protocols;