Clinical Characteristics and Surgical Outcomes of Full-thickness Macular Hole Without Focal Vitreomacular Traction.

This multicenter, retrospective, observational comparative study. We occasionally encounter FTMHs in which PVD has not been achieved and VMT is absent. These FTMHs cannot be defined by stage in the Gass1) or IVTS3) classification. It is not known whether traction is involved in the development of these atypical macular holes, but they are often classified as Gass stage 2 or 3 according to the size of the hole.

The aim of this study was to investigate the clinical features and surgical outcomes of FTMHs without focal VMT and to discuss possible underlying mechanisms.

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Key information

Conditions

Macular Holes Eye Diseases Retinal Diseases Retinal Perforations

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The clinical characteristics and surgical outcomes the patients diagnosed with FTMH without focal VMT in the macula (classified as VMT-) are presented, in addition to a comparative analysis of the patients presenting with classic stage 2 FTMH with focal VMT (classified as VMT+) according to international classification criteria.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

macular hole without posterior vitreous detachment at the fovea

Exclusion criteria

macular hole with posterior vitreous detachment at the fovea
Stage1.3.4 macular hole
Macular hole-associated retinal detachment
Macular hole with subretinal hemorrhage
Traumatic MH

Treatment and study plan

vitrectimy

Other

Clinical characteristics and surgical outcomes

Primary outcomes

postoperative visual acuity

Time frame: 1month, 3, 6 and 12 months

logMAR visual acuity

Secondary outcomes

postoperative status of outer retinal layer in OCT B-scan images

Time frame: 1month, 3, 6 and 12 months

External limiting mambrane, Elipsoid zone, Interdegitaion zone

Sponsors and collaborators

Lead sponsor

St. Marianna University School of Medicine

Other

Collaborators

Takaoka city Hospital
University of Toyama

Registry information

Important dates

Study start: 2016
Primary completion: 2024
Study completion: 2024
First posted: Aug 19, 2024
Registry last updated: Aug 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed