Clinical Assessment of a New Catheter Surface Coating With Antimicrobial Properties

The risk of catheter-related bloodstream infection depends on catheter type, method and site of insertion, aseptic technique and number of manipulations. To address this problem, efforts have focused on engineering biomaterials and surfaces with antibacterial properties to prevent bacteria adhesion and biofilm formation.

In view of the necessity to reduce catheter-related bloodstream infections and of the inadequacy of currently available antimicrobially coated devices, a new antimicrobial catheter surface was developed.

Among other factors, the mode and quality of catheter handling and care of exit site is an important aspect with respect to catheter-related infections.

The clinical study aims at providing data on antimicrobial efficiency of the 2 types of CE certified double lumen catheters and a supposed additional preventive effect of intense hygiene training on catheter-related infections.

Inclusion criteria

• central venous catheter placement
• Need for extracorporeal renal replacement therapy (acute and chronic renal failure)
• Age over 18 years
• Written informed consent
• Needed catheter length 15 cm or 20 cm

Exclusion criteria

• Known infectivity with Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV)/Human Immunodeficiency Virus (HIV)
• Any infection associated with one or more positive blood cultures within 10 days prior to catheter implantation
• Bacteremia with a former catheter within 10 days prior to catheter implantation
• Known pregnancy
• Lactation
• Participation in another clinical study during the preceding 30 days