Clinical Aspect of Erosive Pustular Dermatosis of the Leg

Erosive pustular dermatosis of the leg is a fairlyrecent clinical entity that was described the first time in 1987.

Diagnosis of erosive pustular dermatosis of the leg is made on clinical grounds. It presents as non-follicular pustules of variable size and numbers that rapidly give way to erosions and crusts on one or both legs, and which are found in particular on the anterior aspect of the middle third of the leg (. The lesions are of chronic progression, despite topical therapy. Erosive pustular dermatosis of the leg is seen in elderly patients, mainly female, and may be associated with chronic venous insufficiency or cutaneous atrophy. In the absence of specific criteria and because of the existence of misleading clinical forms, diagnosis is based upon exclusion.

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Key information

Conditions

Erosive Pustular Dermatosis of the Leg Cardiovascular Diseases Vascular Diseases Venous Insufficiency

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Damien JOLLY

Reims, France

About this study

The primary objective of this investigation was to describe the different clinical aspects of cases of Erosive pustular dermatosis of the leg.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

non-follicular pustules and multiple erosions on one or both legs showing no evidence of improvement after application of compression in the event of clinical signs of chronic venous insufficiency and showing no improvement following treatment with local and/or systemic antibacterial therapy, fungal samples from the pustules negative on direct examination, negative direct immunofluorescence results for biopsy samples (taken from around the lesion)

Exclusion criteria

age < 18 years old

Treatment and study plan

Clinical examination

Other

Primary outcomes

Lesions location

Time frame: Day 0

Anterior or posterior leg face
number of lesions

Time frame: Day 0

Less than 10 erosions, between 10 and 50 erosions and more than 50 erosions
Presence of chronic venous insufficiency

Time frame: Day 0

Diagnosis based on the CEAP 2004 Score (Eklöf B, Rutherford RB, Bergan JJ, Carpentier PH, GloviczkiP, Kistner RL, et al. Revision of the CEAP classification forchronic venous disorders: consensus statement. J Vasc Surg2004;40:1248-52)

Sponsors and collaborators

Lead sponsor

CHU de Reims

Other

Registry information

Acronym: Clin-EPDL

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2015
First posted: Aug 9, 2018
Registry last updated: Aug 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed