Clinical Applications of Domperidone in Patients With Delayed Gastric Emptying

The purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy

Completed

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Key information

Conditions

Digestive System Disease Digestive System Diseases

Age range

12 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Division of Gastroenterology, Mt. Sinai Medical Center, Miami Beach, Florida, United States

About this study

This is a study on the effectiveness of domperidone, which increases movement through the digestive system for relief of symptoms, in patients who have delayed gastric solid-phase emptying

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Persistent esophagitis
Heartburn
Nausea
Vomiting
Severe dyspepsia
Severe chronic constipation

Exclusion criteria

History of, or current arrhythmias including ventricular tachycardia, - Ventricular fibrillation and Torsade des Pointes.

Treatment and study plan

Domperidone

Other

Domperidone dosage may be increased depending on how well the patient responds. However before increasing the dosage, patients will have follow-up EKG to evaluate any possible side effects including irregular heartbeats.

Other names: Motilium, Motillium

Primary outcomes

Clinical Applications of Domperidone in Patients with Refractory Gastroesophageal Reflux Disease (GERD)or Delayed Gastric Solid-Phase Emptying

Time frame: 5 years

GERD or Delayed Gastric Emptying

Sponsors and collaborators

Lead sponsor

Mt. Sinai Medical Center, Miami

Other

Registry information

Official study title

Clinical Applications of Domperidone in Patients With Refractory Gastroesophageal Reflux Disease or Delayed Gastric Solid-Phase Emptying

Important dates

Study start: 2007
Primary completion: 2015
Study completion: 2015
First posted: May 1, 2013
Registry last updated: May 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed