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NCT Number: NCT07534787

Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge

This study aims to evaluate the tissue biotype and bone density around dental implants in patients with narrow alveolar ridge. Ridge splitting with simultaneous implant placement covered with concentrated growth factor (CGF) membranes will be performed. Clinical and radiographic evaluation will be done using periodontal probe and CBCT. Pain will also be assessed using visual analogue scale (VAS) during follow-up period.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo university, Cairo, Egypt

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About this study

This study is a case series conducted at the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. It aims to evaluate the tissue biotype and bone density around dental implants in adult patients with narrow alveolar ridge.

Alveolar ridge resorption and soft tissue shrinkage after tooth extraction represent a major problem affecting both aesthetics and function. Therefore, preserving alveolar bone and improving soft tissue conditions are essential for successful implant placement. The use of concentrated growth factor (CGF) membranes combined with ridge splitting and simultaneous implant placement may enhance healing, reduce postoperative pain, and improve tissue biotype and bone density.

All patients will undergo clinical and radiographic assessment before the procedure. Preoperative CBCT will be used for surgical planning. Tissue thickness will be measured using a periodontal probe. During surgery, ridge splitting will be performed followed by implant placement, and CGF membranes will be applied over the grafted area. Autologous bone chips will be used for augmentation.

Postoperative evaluation will include assessment of tissue biotype, bone density using CBCT, and pain using visual analogue scale (VAS). Follow-up will be carried out immediately after surgery and up to 4 months postoperatively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

Patients with narrow alveolar ridge indicated for implant placement Age between 20 and 50 years Good general health Patients with adequate oral hygiene

Exclusion criteria

  • Patients with systemic diseases affecting bone healing Smokers Pregnant or lactating females Patients with poor oral hygiene Patients with history of radiation therapy in the head and neck region

Treatment and study plan

Ridge splitting

Procedure

Patients with narrow alveolar ridge will undergo ridge splitting procedure using chisel to allow implant placement.

Dental implant placement

Procedure

Intervention Description:

Dental implants will be inserted simultaneously after ridge splitting in the prepared alveolar ridge.

Concentrated Growth Factor (CGF)

Biological

CGF membranes will be prepared from patient venous blood and placed over the grafted area to enhance healing and tissue regeneration.

Primary outcomes

  1. Pain (VAS score)

    Time frame: 1st day and 3rd day postoperative

    Pain will be assessed using Visual Analogue Scale (VAS) ranging from 0 to 10.

Secondary outcomes

  1. Tissue biotype thickness

    Time frame: Immediately postoperative and after 4 months

    Tissue biotype will be assessed using a periodontal probe and measured in millimeters.

Other outcomes

  1. Bone density

    Time frame: Immediately postoperative and after 4 months

    Bone density will be evaluated using CBCT and measured in Hounsfield units (HU).

Study contacts

Contact information is provided by the study sponsor or research team.

Tasneem Farrag Ayoub, Master

CONTACT

[email protected]

+201125888649 ext. +201146245469

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge (Case Series).

Acronym: CGF

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 16, 2026
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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