Skip to main content
OpenTrials
Completed

NCT Number: NCT07643402

Clinical and Jaw Tracking Assessment Following Intra-articular Injection of PRP and HA in TMJ Disc Displacement With Reduction

Assessment of intra-articular injection of hyaluronic acid and prp within TMJ using the Zebris jaw tracking device as an objective method

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Temporomandibular Joint Disc Displacement, With Reduction Central Nervous System Diseases Central Nervous System Infections Craniomandibular Disorders Dyssomnias Infections Insomnia, Fatal Familial Jaw Diseases Joint Diseases Mandibular Diseases Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurodegenerative Diseases Prion Diseases Sleep Disorders, Intrinsic Sleep Initiation and Maintenance Disorders Sleep Wake Disorders Stomatognathic Diseases Temporomandibular Joint Disorders

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Mansoura university

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patients' ages range from 18 to 45.
  • Patients experienced clicking sounds, painful joints, and restricted mouth opening.
  • Individuals whose MRI confirms a unilateral internal abnormality with reduction.
  • A patient who did not respond to conservative treatment. 5 • The patient's capacity and willingness to finish the course of therapy and subsequent appointments.

Exclusion criteria

  • A patient suffering from a connective tissue or inflammatory condition.
  • A patient who has had TMJ surgery in the past.
  • A history of injecting any kind of material into the target TMJ.
  • Drug allergy history.
  • A patient who has previously had fibrous or bony adhesion.
  • A patient experiencing psychological issues.

Treatment and study plan

Hyaluronic Acid (HA) and Platelet rich plasma

Combination Product

A combination of Autologous Platelet-Rich Plasma prepared from the patient's blood and hyaluronic acid injected intra-articularly

Primary outcomes

  1. Mandibular movements assessed using the zebris JMA

    Time frame: Baseline, 1month

    changes in mandibular movements assessed using the Zebris Jaw Motion Analyzer (JMA) system following treatment

Secondary outcomes

  1. Maximum interincisal opening (MIO)

    Time frame: Baseline, 1 week, 1 month, 3 months,6 months

    Changes in maximum interincisal opening measured in millimeters following treatment

  2. Pain Assessment using the Visual Analogue Scale

    Time frame: baseline, 1 week, 1 month, 3months, 6 months

    Changes in pain intensity assessed using the Visual Analog Scale (VAS), a 0-10 scale where 0 indicates no pain and 10 indicates the worst imaginable pain; higher scores indicate greater pain severity. Measurements will be obtained at baseline, 1 week, 1 month, 3 months, and 6 months following intra-articular injection of hyaluronic acid and platelet-rich plasma (PRP) in patients with temporomandibular joint disc displacement with reduction.

  3. clicking sound

    Time frame: Baseline, 6 months

    changes in clicking sound following treatment

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Biomechanical Assessment of Platelet Rich Plasma and Hyaluronic Acid Intra-articular Injection in Temporomandibular Joint Internal Derangement Using a Jaw Tracking Device

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jun 11, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.