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NCT Number: NCT00431483

Clinical and Economic Impact of Interventions by a Clinical Pharmacist on Antibiotic Use on Surgical Wards

The purpose of this study is to establish the impact of a pharmacist's recommendations regarding choice, dosing and duration of antibiotic therapy on quality and cost of antibiotic treatment on surgical wards.

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Key information

Conditions

Bacterial Infections Bacterial Infections and Mycoses Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Luwig Maximilians University - Klinikum Grosshadern

Munich, Bavaria, 81377, Germany

About this study

Inappropriate or incorrect use of antibacterials exerts selection pressure on pathogens potentiating emergence of resistance, puts patients at risk for unnecessary adverse drug reactions and potentially prolongs the length of stay in hospital thus increasing healthcare costs.

In an effort to improve the quality of antibiotic drug therapy on surgical wards of a large university hospital, specific consulting by a clinical pharmacist was established.

The objective of this study is to assess the impact of pharmaceutical consulting on the quality and costs of antibiotic use in surgical wards.

Comparison:

Within a control period the current pattern of antibiotic use is monitored. During the intervention period, the impact of the interventions made by the clinical pharmacist on antibiotic use is examined. One ward serves as a parallel control group; no intervention is being made on this ward throughout this study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • female and male patients receiving antibiotics for a proven or suspected infection on designated surgical wards

Exclusion criteria

  • patients under 18
  • patients unable or unwilling to consent to their data being evaluated
  • patients receiving antibiotics perioperatively as prophylaxis
  • patients receiving antibiotics for less than 48hrs

Treatment and study plan

pharmaceutical consulting

Behavioral

to measure if information and advice by a pharmacist has an impact on quality and quantity of prescribed antibacterials

Primary outcomes

  1. overall duration of antibiotic therapy during study period

    Time frame: Feb 2008

Secondary outcomes

  1. iv to oral switch

    Time frame: Feb 2008

    number of courses of iv antibiotics switched to oral antibiotics; duration of iv treatment

  2. compliance of treatment with hospital formulary for antibiotic therapy

    Time frame: Feb 2008

  3. cost of antibiotic therapy

    Time frame: Feb 2008

  4. number and duration of therapy with antibiotics with redundant spectra

    Time frame: Feb 2008

Sponsors and collaborators

Lead sponsor

Ludwig-Maximilians - University of Munich

Other

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Feb 5, 2007
Registry last updated
Sep 26, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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