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NCT Number: NCT07366645

Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries

The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light application on caries arrest of initial enamel pits and fissure caries for permanent teeth of young adults

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Key information

Conditions

Incipient Caries

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • high caries risk dental students
  • Males or females
  • Medically free
  • Not taking medication
  • At least had one active carious tooth
  • Posterior permanent teeth
  • ICDAS 2

Exclusion criteria

  • non-Egyptian students
  • Lack of compliance
  • Allergic reaction to the materials used
  • Pregnancy
  • Dental students cannot give consent
  • Teeth that will be extracted for orthodontic reasons
  • Dental fluorosis
  • Hypo calcified teeth
  • Systemic diseases affecting teeth, such as amelogenesis imperfecta
  • Severe periodontal affection

Treatment and study plan

International Sliver Diamine Fluoride

Other

It is the gold standard; it is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.

Local brand Egyptian Silver Diamine Fluoride

Other

It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.

Silver Fluoride

Other

It is a water-based remineralizing agent with an application time of 60 seconds.

International Sliver Diamine Fluoride with LED light

Other

It is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.

Local brand Egyptian Silver Diamine Fluoride with LED light

Other

It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED application for 20 seconds.

Silver Fluoride with LED light

Other

It is a water-based remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.

Primary outcomes

  1. Caries arrest

    Time frame: After 3, 6, and 12 months.

    Lesion activity will be assessed by caries status (active/inactive) using visual and tactile inspection for surface discontinuities and texture. The participants will be examined under unit light using a 0.5 mm ball-ended (CPI) probe and a dental mirror. The teeth will be cleaned and dried by a water-air spray syringe before the examination.

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Clinical Efficacy and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride to Arrest Incipient Carious Lesions in Permanent Molar Teeth With or Without Application of LED Light: A Randomized Clinical Trial

Acronym: SDF and AgF

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 26, 2026
Registry last updated
Jan 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.