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NCT Number: NCT05572385

Clinic and Neurophysiology of Aphasia Treatment

In the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

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Key information

Conditions

Aphasia, Acquired Aphasia Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. Here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. Of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. In the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - CIAT) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. The aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (EEG) parameters such as event-related potentials (N400, P600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with a cerebrovascular event

Exclusion criteria

  • premorbid brain disorder

Treatment and study plan

CIAT + Conventional neurorehabilitative therapy

Behavioral

CIAT = Constrained induced aphasia therapy

Other names: Conventional neurorehabilitative therapy

Primary outcomes

  1. EEG correlates of language reconstitution

    Time frame: 3-6 months after stroke

    Identitification of EEG features (N400, P600, Theta band activity) that correlate with clinical outcome of language reconstitution.

Sponsors and collaborators

Lead sponsor

Klinik Bavaria

Other

Registry information

Official study title

Clinical and Neurophysiological Features of Neurorehabilitation Effects in Cerebrovascular Aphasia

Acronym: AphasRehab

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Oct 7, 2022
Registry last updated
Oct 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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