CLIME-CJD: A Multimodal Study

Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurological disorder. This study aims to describe and summarize the key features of CJD by looking back at medical records of patients who were diagnosed with CJD at our hospital. The researchers will collect information from routine clinical evaluations, including patients' symptoms, blood tests, cerebrospinal fluid analysis, brain imaging (such as MRI and PET), and electroencephalography (EEG). By analyzing these data together, the study hopes to provide a clearer picture of how CJD presents in routine clinical practice. This may help doctors recognize the disease more quickly in the future. No new tests or treatments will be given to patients. All data are collected from existing medical records.

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Key information

Conditions

Creutzfeldt-Jakob Disease (CJD) | Prion Disease Brain Diseases Central Nervous System Diseases Central Nervous System Infections Creutzfeldt-Jakob Syndrome Dementia Infections Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Prion Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Fujian Medical University

Fuzhou, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of definite or probable Creutzfeldt-Jakob Disease (CJD) according to the established WHO diagnostic criteria
Available medical records covering at least one of the following: clinical history, peripheral blood test results, cerebrospinal fluid (CSF) analysis findings, brain MRI reports/images, or EEG reports
Hospitalized or evaluated at the participating institution during the study period

Exclusion criteria

Alternative diagnosis confirmed that explains all clinical features (e.g., autoimmune encephalitis, rapidly progressive dementia due to other causes)
Incomplete medical records with no relevant clinical, laboratory, imaging, or EEG data available
Patient or legal representative declined the use of medical records for research purposes (where applicable according to local regulations)

Treatment and study plan

No interventions

Other

No Interventions

Primary outcomes

Proportion of CJD Patients With Characteristic Diagnostic Findings

Time frame: Baseline

The primary outcome is the proportion of patients showing characteristic abnormalities across five domains: clinical symptoms, peripheral blood markers, cerebrospinal fluid 14-3-3 protein and RT-QuIC, brain MRI (cortical ribboning or basal ganglia hyperintensity), and EEG (periodic sharp wave complexes).

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Fujian Medical University

Other

Registry information

Official study title

A Multimodal Retrospective Cohort Analysis of Clinical, Laboratory, Neuroimaging, Electroencephalographic, and Biomarker Characteristics in Patients With Creutzfeldt-Jakob Disease: The CLIME-CJD Study

Important dates

Study start: 2022
Primary completion: 2031
Study completion: 2031
First posted: May 15, 2026
Registry last updated: May 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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