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Completed

NCT Number: NCT03215680

Climat Impact on Urinary Iodine Concentration

Urinary iodine concentration (UIC) is the recommended biomarker of iodine status in populations. Yet, the influence of climate on UIC remains unclear. Hot climate may reduce urine volume and consequently increase UIC independent of iodine status. This could lead to an overestimation of population iodine intake, thus masking iodine deficiency in vulnerable groups.

In this longitudinal observational cohort study in women of reproductive age we will collect 24h and spot urine samples in the summer and winter season. The influence of high temperature climates on UIC, measured and estimated urinary iodine excretion will be estimated.

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Key information

Conditions

Iodine Deficiency

Age range

18 year–49 year

Sex eligibility

Female

Study type

Observational

Primary location

Centre of Excellence for Nutrition, Faculty of Health Science, North West University, Potchefstroom, South Africa

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Female
  • Non-pregnant and non-lactating
  • General good health, assessed by no reported treatment for chronic disease
  • Non-smoking
  • No known history of major medical illnesses or thyroid dysfunction as well as gastrointestinal or metabolic disorders and taking no chronic medication
  • Residence at the respective study site for 12 months or longer and no plans of moving away during the study year.
  • No use of iodine containing dietary supplements during the last 6 months
  • No use of X-ray / CT contrast agent or iodine containing medication within the last year
  • No use of iodine containing disinfectants during the last 6 months
  • Participants should be between 18 and 49 years at date of enrollment

Treatment and study plan

Climate

Other

Hot and temperate climate

Primary outcomes

  1. Urinary iodine concentration

    Time frame: 6 months

    Measured in 24h urine collections

Secondary outcomes

  1. Urinary iodine excretion

    Time frame: 6 months

    Measured in 24 h urine collections

Other outcomes

  1. Urinary iodine concentration

    Time frame: 6 months

    Measured in spot urine samples

  2. Urinary iodine excretion

    Time frame: 6 months

    Measured in spot urine samples

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Collaborators

  • Ministry of Health, Tanzania
  • North-West University, South Africa

Registry information

Official study title

Assessment of Impact of High Temperature Climate on Urinary Iodine Concentration in Women of Reproductive Age

Acronym: LION

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jul 12, 2017
Registry last updated
Mar 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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