Clear Cell Chondrosarcoma in Italy

Clear cell chondrosarcoma of bone is considered a low-grade malignant tumor in the last WHO classification of soft tissue and bone tumors; however, it is reported that recurrences and metastasis can occur. Considering the uncertain prognosis of this rare tumor, with some cases that historically seems to pursue a bad prognosis, we decided to collect all the Italian cases of clear cell condrosarcoma, in order to better understand its natural history and prognosis.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Chondrosarcoma Chondrosarcoma, Clear Cell Neoplasms Neoplasms by Histologic Type Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Sarcoma

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

IRCC Rizzoli Orthopedic Institute

Bologna, 40136, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male and female patients with diagnosis of clear cell chondrosarcoma and chondrosarcoma with a clear cell component treated from 01 Jan 1982 to 31 Dec 2023
Information available (date of primary tumor diagnosis, local treatments, systemic treatment, response to systemic treatment, date of progression) and date and status at last follow-up
Imaging studies available for revision
Histological slides available for revision

Exclusion criteria

- Diagnosis different from clear cell chondrosarcoma or chondrosarcoma with a clear cell component;
Absence of radiological and/or clinical data

Treatment and study plan

Molecular studies

Genetic

Molecolar studies to define possible prognostic parameters

Primary outcomes

Prognostic accuracy

Time frame: At baseline

Ability of the model to predict overall survival, measured by AUC/C-index

Sponsors and collaborators

Lead sponsor

Istituto Ortopedico Rizzoli

Other

Collaborators

A.O.U. Città della Salute e della Scienza
Azienda Ospedaliero, Universitaria Pisana
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Gaetano Pini CTO, Milano
IRCCS Humanitas Research Hospital, Milano
Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale
Ospedale "Morgagni - Pierantoni" di Forlì

Registry information

Official study title

Clear Cell Chondrosarcoma in Italy: Insights Into Radiological, Clinical and pathologicaL Features, With Emphasis on Prognosis (CIRCLE)

Acronym: CIRCLE

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2026
First posted: Jan 22, 2026
Registry last updated: Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting