CLE-PAD : Prevalence of PAD in Patients With Surgically Lumbar Spinal Stenosis

Lumbar spinal stenosis (LSS) is a debilitating degenerative condition in older people associated with lower back pain, pain in the lower limbs and a reduced quality of life. LSS can be treated surgically, but the results are mixed: 35% of patients report low satisfaction one year after surgery. The symptoms of LSC in the lower limbs can mimic those associated with peripheral arterial disease (PAD). The prevalence of PAD in the LSC population varies between 4.1% and 67.8% depending on the diagnostic tests used and the populations studied. Thus, the precise analysis of the prevalence of PAD and the sensitivity and specificity of PAD diagnostic tests in this population remain to be determined. These analyses would help to optimise PAD diagnostic tools, while possibly providing an explanation for the post-operative persistence of functional discomfort in CLE patients. Furthermore, a better understanding of the vascular system in the CLE population offers hope for optimising patient care, both from a medical and a medico-economic point of view.

The experimental visit takes place as soon as possible after receipt of the biological assessment and within a maximum period of 3 months. During this visit, specific research examinations will be performed, including stress tests (stress TcPO2 according to the modified Strandness protocol and stress TcPO2 according to the Gardner-Skinner increasing load protocol), as well as an injected scan of the aorta of the lower limbs. The pseudonymised CT scan will be sent to the sponsor for blind review. A follow-up telephone call will be made between 7 and 10 days after the CT scan to detect the occurrence of any adverse events. The study will then be completed for the participant.

Inclusion criteria

• Presenting with a lumbar spinal stenosis with surgical indication, either unoperated or operated on less than 3 months ago
• Affiliated with a social security scheme
• Having received oral and written information about the protocol and having signed a written consent form to participate in this research.

Exclusion criteria

• emergency surgical care
• Contraindication to contrast enhanced CT scan

• Stroke or myocardial infarction (MI) within the last 3 months
• Known severe or poorly tolerated arrhythmia
• Known severe or symptomatic left ventricular outflow obstruction
• Decompensated heart failure
• History within the last 3 months of venous thromboembolic disease, myopericarditis, endocarditis, aortic dissection or intracardiac thrombus
• Severe uncontrolled hypertension (BP > 200/110 mmHg)
• Inability to walk on the treadmill
• Major lower limb amputation
• Adult subject to legal protection