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Completed

NCT Number: NCT06648603

Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa

This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

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Key information

Conditions

Dengue Arbovirus Infections Flaviviridae Infections Flavivirus Infections Hemorrhagic Fevers, Viral Infections Mosquito-Borne Diseases RNA Virus Infections Vector Borne Diseases Virus Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Suisse de Recherches Scientifiques en Côte d'Ivoire

Abidjan, Côte d’Ivoire

About this study

This project targets the growing threat of Aedes mosquito-borne diseases such as dengue in Africa, focusing on the Anono and Gbagba communities in Abidjan, Ivory Coast, by transitioning from traditional control approaches to a community-driven strategy. It focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. The approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. A randomized controlled trial (RCT) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of Aedes mosquito and other arboviruses. This effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Geographical location: households must be located within the designated clusters in the two districts involved in the trial.
  • Participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. Control, 2. Community-based larval source management, 3 Enhanced Aedes adults trapping (BG-GAT), 4. Enhanced Aedes adults trapping (BG-GAT) + Community-based larval source management).
  • Willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys.
  • Socio-Environmental Data: households must agree and provide consent to participate to the socio-environmental questionnaire.

Exclusion criteria

  • Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
  • Refusal to participate: households that do not consent to mosquito trap placement or surveys
  • Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Treatment and study plan

Community-based larval source management

Behavioral

This project will foster active engagement with community stakeholders, including healthcare workers, community leaders, and other key informants, through participatory meetings aimed at co-creating and developing larval source reduction measures tailored to community's needs. This method emphasizes a participatory framework, ensuring that interventions are both community-informed and culturally relevant.

Enhanced Aedes adults trapping (BG-GAT)

Device

Furthermore, the project intends to determine whether the addition of cost-effective, gravid female mosquito-targeting traps, specifically two Biogents Gravid Aedes Traps (BG-GAT) per household, can improve the overall success of these community-based intervention.

Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)

Combination Product

The community-based interventions and the BG-GAT deployment will be evaluated in combination to assess their individual and synergistic effects on vector control. This dual strategy combines local participation and practical, evidence-based solutions to address mosquito-borne illness transmission.

Primary outcomes

  1. Aedes aegypti mean number per trap per day

    Time frame: Continuously during months 1-4 (baseline) and months 5-17 (trial)

    Biting rate is the mean number of Aedes females per trap and per day. The proportion of unfed, fed, half-gravid and gravid females will be estimated.

Secondary outcomes

  1. House index

    Time frame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

    House index: proportion of houses with at least one larva

  2. Pupal indices: pupae per person index, pupa index and pupae per hectare index

    Time frame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

    Pupae per person index: number of pupae per person Pupa index: number of pupae per house Pupae per hectare index: number of pupae per ha

  3. Adults: parity rate

    Time frame: Continuously during months 1-4 (baseline) and months 5-17 (trial)

    The parity rate (PR) (proposition of parous females) will be calculated to estimate vector longevity.

  4. Knowledge, attitudes, and practices on Dengue prevention among the population of Cocody-Bingerville

    Time frame: Before (month 1) the start of the trial and at the end of the trial (month 12)

    A Knowledge, Attitudes, and Practices (KAP) study will be conducted to assess the communities' understanding, attitudes, practices, and beliefs related to dengue. This will be done using a structured questionnaire developed specifically for this trial. The questionnaire comprises both multiple-choice and open-ended questions, allowing for a comprehensive assessment of: 1) Knowledge: Understanding of dengue transmission, symptoms, and prevention, 2) Attitudes: Perceptions of dengue risk and confidence in prevention methods, 3) Practices: Reported behaviors to prevent dengue, such as mosquito control measures. This structured tool will be used at both baseline and endline to measure changes and assess the effectiveness of the intervention."

  5. Mapping and describe Aedes aegypti breeding sites, focusing on their geographic and ecological characteristics. This mapping will be used to enhance targeted larval control efforts in these areas.

    Time frame: Before (month 1) the start of the trial and at the end of the trial (month 12)

    The geographic survey will collect household and environmental data, including demographic details, public space quality, water provision, sanitation access, and waste management practices. It will map housing conditions, examining building types, construction materials, and key features like water storage and solid waste management. The survey will also assess local built environments to inform interventions for improving living conditions and controlling mosquito breeding sites.

  6. Container index

    Time frame: before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

    Proportion of positive containers

  7. Breteau index

    Time frame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

    Number of positive containers per 100 houses

Sponsors and collaborators

Lead sponsor

Swiss Tropical & Public Health Institute

Other

Collaborators

  • Centre Suisse de Recherches Scientifiques en Cote d'Ivoire

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 18, 2024
Registry last updated
Oct 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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