Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)

Specific Objectives:

• To compare Cirrus HD-OCT automated measurements of the illumination area under the RPE to expert manual measurements of areas of hypofluorescence typical of geographic atrophy in fundus autofluorescence (FAF) images.
• To describe the differences and similarities between Cirrus HD-OCT and fundus autofluorescence images of subjects with geographic atrophy secondary to dry age-related macular degeneration (AMD).
• To determine the clinical factors that affect the Cirrus HD-OCT automated measurements of the illumination area under the RPE.

Inclusion criteria

• Males or females 50 years of age and older diagnosed to have advanced dry AMD with geographic atrophy.
• Geographic atrophy lesions should:

• Not be greater than 5 mm at the widest diameter. The entire lesion(s) should fit into the 6x6 mm scan area of the Cirrus HD-OCT.
• Not be smaller than 1.25 mm2.
• Not be confluent with peri-papillary atrophy.
• Not be combined with other lesions such as CNVs.
• Able and willing to make the required study visit.
• Able and willing to give consent and follow study instructions.

Exclusion criteria

• History of retinal surgery, laser photocoagulation, and/or radiation therapy to the eye.
• Evidence of other retinal diseases of the eye, including wet AMD, diabetic retinopathy, diabetic macular edema, or significant vitreomacular traction upon dilated examination, or upon evaluation of retinal photos.
• Thick media opacity or inability to fixate that precludes obtaining acceptable scans.
• Concomitant use of hydrochloroquine and chloroquine.
• Unable to make the required study visit.
• Unable to give consent or follow study instructions.