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OpenTrials
Completed

NCT Number: NCT00862290

Circulating microRNAs as Biomarkers of Sepsis

MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Changhai Hospital, Second Military Medical University

Shanghai, 200433, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who develop sepsis and undergo abdominal surgery
  • patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

Exclusion criteria

  • patients with a primary diagnosis of acute pancreatitis
  • patients with cirrhosis or renal dysfunction
  • patients with dyscrasia
  • patients with autoimmunity diseases
  • patients with severe cardiac and pulmonary diseases
  • patients with hematological diseases
  • patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass

Treatment and study plan

Primary outcomes

  1. Relative amount of circulating microRNAs

    Time frame: On the second day of diagnosis of sepsis in ICU

Secondary outcomes

  1. Serum levels of CRP and IL-6

    Time frame: On the second day of diagnosing sepsis

  2. Apache II score and death

    Time frame: On the second day of diagnosis of sepsis

Sponsors and collaborators

Lead sponsor

Changhai Hospital

Other

Registry information

Official study title

Diagnostic and Predictive Value of Circulating microRNAs During Sepsis

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Mar 16, 2009
Registry last updated
May 3, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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