Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY

Inclusion criteria

For the patients :

• Adult patient (≥ 18 years) suffering from drug-resistant focal epilepsy or from drug-resistant generalized epilepsy according to ILAE classification
• Patient undergoing long-term video-EEG monitoring in Epilepsy unit of Lyon to record and characterize her/his seizure
• Patient who gave her/his written informed consent to participate to the study
• Patient affiliated to the French health care system

For the healthy volunteers :

• Adult (≥ 18 years)
• Without history of neurological disorders and/or psychiatric disorders, and/or general medical disorders
• Subject who gave her/his written informed consent to participate to the study
• Subject affiliated to the French health care system

Exclusion criteria

For the patients :

• Ongoing major depressive episode as defined by a score ≥ 15 at the French version of the NDDI-E scale*
• Current panic disorder as defined by a score ≥ 7 at the French version of the GAD-7 scale*
• Ongoing treatment with selective serotonin reuptake inhibitor
• Patient who benefit from a protective measure

For the healthy volunteers :

• Presence of the symptoms of anxiety and/or depression as defined by a score ≥ 11 at the French version of the Hospital Anxiety and Depression Scale (HADS)
• Ongoing treatment with selective serotonin reuptake inhibitor
• Subjects with these psychiatric comorbidities and/or treatment will be excluded in order to limit risk that the relation previously reported between miR-135a, miR-16, miR-1202 and depression and/or panic disorder and/or response to selective serotonin