Circulating Factors in Nephrotic Syndrome

A prospective observational study to investigate the treatment-associated changes of circulating factors associated with glomerular diseases among patients with de novo nephrotic syndrome admitted to hospital for a kidney biopsy.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Nephrotic Syndrome Autoimmune Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glomerulonephritis Glomerulonephritis, Membranous Immune System Diseases Kidney Diseases Male Urogenital Diseases Membranous Nephropathy Minimal Change Disease Nephritis Nephrosis Nephrosis, Lipoid Primary Focal Segmental Glomerulosclerosis Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years
Plasma albumin < 36 g/L
Urine protein >3.5 g/day or urine protein/creatinine-ratio (UPCR) > 3.5 or urine albumin/creatinine-ratio (UACR) >2200 mg/g
Planned kidney biopsy
Able to give written informed consent

Exclusion criteria

Kidney transplant recipient
Previously undergone a kidney biopsy
Unable to understand written information in Danish

Treatment and study plan

observation

Other

Observation

Primary outcomes

levels of anti-nephrin in blood by ELISA

Time frame: up to 12 months

temporal association of anti-nephrin with clinical remission of nephrotic syndrome

Secondary outcomes

changes in auto-antibodies in blood associated with membranous nephropathy

Time frame: up to 24 months

temporal association of auto-antibodies with clinical remission of nephrotic syndrome

Study contacts

Contact information is provided by the study sponsor or research team.

Ditte Hansen, MD PhD

CONTACT

[email protected]

+4538682056

Iain Bressendorff, MD PhD

CONTACT

[email protected]

+4524277139

Sponsors and collaborators

Lead sponsor

Iain Bressendorff

Other

Registry information

Official study title

Circulating Factors in Nephrotic Syndrome - A Prospective Observational Cohort Study

Important dates

Study start: 2024
Primary completion: 2034
Study completion: 2034
First posted: Mar 18, 2024
Registry last updated: Mar 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting