Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

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Key information

Conditions

Endothelial Dysfunction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Frédéric GAGNADOUX

Angers, 49933, France

About this study

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion.

the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI >15).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult subject
Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent
Subject with OSA (defined by AHI >15/h)

Exclusion criteria

cardiac or vascular desease

Treatment and study plan

ENDOPAT

Diagnostic Test

digital plethysmography

Primary outcomes

miRNA cointained in exosomes

Time frame: immediately after the consultation

compare exosome content between obese-OSA patients with endothelial dysfunction and without

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Registry information

Official study title

Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome(OSA): EXODYS

Acronym: EXODYS

Important dates

Study start: 2021
Primary completion: 2023
Study completion: 2023
First posted: Jul 7, 2020
Registry last updated: Jun 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed