Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up

patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.

upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history.

blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.

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Key information

Conditions

Inflammatory Bowel Diseases Chronobiology Disorders Circadian Dysregulation Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Intestinal Diseases Nervous System Diseases

Age range

6 year–25 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis.
Both male and female
Age 6-25 years
Medically treated for IBD in our institute.

Exclusion criteria

Genetic disorder.
Known primary or secondary immunodeficiency .
Pregnancy or lactating

Treatment and study plan

no intervention performed- observational only

Other

no intervention performed- observational only

Primary outcomes

clock gene expression levels in intestinal mucosal samples and WBC peripheral blood.

Time frame: 4 years

PCR amplification levels

Sponsors and collaborators

Lead sponsor

Tel-Aviv Sourasky Medical Center

Other Gov

Registry information

Official study title

Clock Gene Disruption May be an Initial Manifestation of IBD and Celiac .

Important dates

Study start: 2017
Primary completion: 2022
Study completion: 2022
First posted: Sep 7, 2018
Registry last updated: Feb 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed