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Completed

NCT Number: NCT07169721

CIRCAdian Rhythm of the IMMune Age IndeX (IMMAX)

The goal of this observational study is to evaluate the influence of circadian rhythms on the determination of an individual's immune age. The biomarker IMMAX was calculated for 50 participants aged 20-69 at 8 a.m., 1 p.m. and 6 p.m. on the same day.

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Key information

Conditions

Healthy Subjects Immune Cells (Mucosal and Systemic)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Leibniz Research Centre for Working and Environment and Human Factors

Dortmund, 44139, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged > 18 years
  • knowledge of German or English sufficient to provide verbal explanations and obtain written consent

Exclusion criteria

  • exercise on the assessment day
  • acute infection
  • vaccination within the last 4 weeks
  • autoimmune disease
  • cancer
  • drugs that may influence immune cell counts
  • participation in other interventional studies during study period

Treatment and study plan

Primary outcomes

  1. Changes in the Immune Age Index Immune Age Index (IMMAX) from morning to midday and evening

    Time frame: From 8 a.m. until 6 p.m. on the same day

    To determine the Immune Age Index, 100 µl blood is collected and immunostained with antibodies. The immune cells are then analyzed using flow cytometry. IMMAX values range from 0 to 1 with higher values indicating a higher immune age.

Sponsors and collaborators

Lead sponsor

Leibniz Research Centre for Working Environment and Human Factors

Other

Registry information

Official study title

CIRCAdian Rhythm of the IMMune Age IndeX (CIRCA-IMMAX) - Influence of Circadian Rhythm on the Determination of an Immune Age Metric

Acronym: CIRCA-IMMAX

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 12, 2025
Registry last updated
Sep 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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