Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer

Inclusion criteria

• Histologically proven non small cell lung cancer
• Inoperable tage IIIA or IIIB non small cell lung cancer
• Age ≥ 18 years
• PerfLife expectancy ≥6 months
• Hematological function : neutrophils ≥1500/mm3 and platelets ≥ 100000/mm3
• Hepatic function: Bilirubin within normal limits et AST and ALT ≤ 2 times the upper limit of normal (ULN).
• Renal function: Creatinine ≤ 1.5 times ULN.
• Absence of cardiac insufficiency, absence of unstable angina, absence of arrythmia
• Patient has health insurance coverage.
• Signed informed consent.

Exclusion criteria

• Patients previously treated for a malignancy by means of chemotherapy, radiotherapy or surgery.
• Uncontrolled hypertension
• Uncontrolled bleeding within the last 3 months.
• Patients under anti-coagulation with anti-vitamin K or therapeutic dose heparin ; low-molecular heparins for prophylaxis are permitted and are not considered an exclusion criterion.
• Presence of cerebral metastases.
• Participation in a clinical trial within the last 8 weeks.
• Any other specific concomitant anti-tumor treatment (such as chemotherapy, radiotherapy …).
• Patients with a history of myocardial infarction or a cerebral vascular accident within the last 12 months.
• Continued use of aspirin (>325mg/day)
• Major surgery whiting the last 28 days or planned.
• Major non-healing wound, ulcer
• Pregnant or breastfeeding women cannot participate in this trial. Women of reproductive potential must have a negative pregnancy test (blood) within 72 hours before the start of treatment.
• Men and women of reproductive potential must use an efficient contraceptive method when entering the trial and until one months after the end of treatment.
• History of a thrombo-embolic or hemorrhagic event.
• Patients put under tutelage.
• Patients not able to follow the procedures visits, exams foreseen by the trial.
• Any other severe medical or psychiatric condition or biological anomaly - acute or chronic - that, in the investigator's opinion - may render the inclusion of the patient inappropriate.