Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06092749

Chronic Unilateral Lumbar Radicular Pain

Chronic neuropathic lumbar pain is among one of the most widespread complaints of patients.Many approaches have been attempted to target chronic pain, with varying efficacy and risks. Transgrade (TG) epidural injection is a new technique using a Racz- Coudé needle for epidural access at a "transgrade" angle without requiring any specialized hardware or accessories. Interlaminar (IL) epidural steroid injection (ESI) is one of the procedures that involves the delivery of injectate to the epidural space through directing a needle between the laminae of two adjacent vertebrae.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Neuropathic Pain Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ain-Shams University Hospitals

Cairo, Egypt

Location status: Recruiting

Location contact

Ibrahim Mamdouh Esmat

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • > 6-month history of persistent pain in one leg with back pain.
  • Capable of giving informed consent.
  • Unsatisfactory response to conventional treatments including physical therapy or medications with a numeric rating scale (NRS) ≥ 5.

Exclusion criteria

  • Previous lumbar spinal surgery.
  • Myelopathy.
  • Rheumatoid disorders.
  • Psychiatric disorders
  • Bleeding or coagulation disorders

Treatment and study plan

Transgrade technique (TG)

Other

Transgrade (TG) Epidural Steroid Injection technique

Interlaminar technique (IL)

Other

Interlaminar (IL) Epidural Steroid Injection technique

Primary outcomes

  1. Number of patients who experienced successful pain relief at 3 month post-intervention

    Time frame: 6 month post intervention (study period)

    Number of patients who experienced successful pain relief at 3 month post-intervention, which is defined as ≥ 50% reduction of numeric rating scale (NRS-11) from pre-intervention level.

Study contacts

Contact information is provided by the study sponsor or research team.

Ibrahim Mamdouh Esmat

CONTACT

[email protected]

01001241928

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Effectiveness of Transgrade vs Interlaminar Epidural Steroid Injection for Chronic Unilateral Lumbar Radicular Pain

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Oct 23, 2023
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.