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NCT Number: NCT07237152

Chronic Pain Predictors in Major Trauma

The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture.

The main question it aims to answer is: which risk factors predict which patients will experience chronic pain following traumatic limb injury.

Participants will answer a baseline questionnaire and two outcome questionnaires about their pain at 3 and 6 months after their injury.

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Key information

Conditions

Chronic Pain Limb Fracture Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Queens Medical Centre- Nottingham University Hospitals NHS Trust

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

Location contact

Georgia E Melia, BSc (Hons), MRes

CONTACT

[email protected]

+44 0115 9249924 ext. 87070

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged ≥ 16 Polytrauma patient (multiple injuries affecting multiple body regions or organ systems) Admitted to a UK Major Trauma Centre Minimum of 1 radiologically confirmed traumatic limb fracture Have capacity to provide informed consent to participate in the study Have sufficient proficiency in English to provide the required data or be willing to use an approved interpreting service for data collection Recruited within 4 weeks of injury

Exclusion criteria

No traumatic limb fracture Patients with a primary or treatment amputation in relation to their limb injury Pathological limb fractures Prisoners No fixed abode

Treatment and study plan

Primary outcomes

  1. Presence of chronic pain

    Time frame: Reported at baseline, 3 and 6 months post-injury

    Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).

  2. Severity of chronic pain

    Time frame: Reported at baseline, 3 and 6 months post-injury

    Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).

  3. Pain impact

    Time frame: Reported at baseline, 3 and 6 months post-injury

    Assessed using the six-item pain interference index

Study contacts

Contact information is provided by the study sponsor or research team.

Georgia E Melia, BSc (Hons), MRes

CONTACT

[email protected]

+44 0115 9249924 ext. 87070

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Registry information

Official study title

Risk Factors for Chronic Limb Pain in Major Trauma Patients With Limb Injury

Acronym: COPE: MT

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Nov 19, 2025
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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