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OpenTrials
Completed

NCT Number: NCT01144845

Chronic Pain Following Thoracic Surgery

Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem. Persistent postsurgical (chronic postoperative pain) is the consequence of either ongoing inflammation or more common neuropathic pain as a result of surgical damage to peripheral nerves.

Previous studies have shown that chronic pain is a frequent and serious complication following thoracic surgery. However, the prevalence of chronic pain following both thoracoscopy and anterior thoracotomy in patients with pulmonary malignancies is poorly characterized and the impact of this pain on patients' lives remains unclear. Thus, this study aims to investigate the prevalence of chronic pain following thoracoscopy or anterior thoracotomy, and the severity and impact of persistent post-surgical pain on daily life.

This study is working with several hypotheses: 1.) persistent postsurgical pain following lung cancer surgery is predominantly of neuropathic nature and the presence of neuropathic symptoms increases the severity of postsurgical pain and reduces the patient's quality of life, 2.) the prevalence of chronic pain is reduced over time, and 3.) less invasive thoracic surgical interventions reduces the risk of the development of chronic pain.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby

Aarhus N, DK-8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who previously underwent thoracic surgery with lung resection from January 2000 to december 2009

Exclusion criteria

  • Death

Treatment and study plan

thoracic surgery

Procedure

Thoracoscopy or anterior thoracotomy

Primary outcomes

  1. Presence of persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

Secondary outcomes

  1. Location of persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  2. Duration of postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  3. Course of persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  4. Severity of postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  5. Characteristics of persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  6. Symptoms associated with persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  7. Treatment of and effect of treatment on persistent postsurgical pain

    Time frame: Within 10 years after thoracic surgery

  8. Effect of postsurgical pain on activity, mood, walking ability, work, interpersonal relations, sleep and quality of life

    Time frame: Within 10 years after thoracic surgery

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Study of Persistent Postsurgical Pain Following Thoracic Surgery in Patients With Pulmonary Malignancies

Acronym: PTPS-18

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Jun 16, 2010
Registry last updated
Aug 30, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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