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Completed

NCT Number: NCT06976398

Chronic Neck Pain and Central Sensizitation

Chronic neck pain is one of the musculoskeletal pain problems that can cause chronic disability. It is emphasised that individuals with chronic neck pain have difficulty during different activities in their daily lives, and that this problem is a very common health problem that can lead to disability. In the case of chronic neck pain, changes in the pain threshold cause central sensitisation and individuals become more sensitive to pain stimuli. This situation can affect the processing of proprioceptive information and lead to deterioration in proprioceptive perception. This situation leads to perceptual problems in body and neck awareness. Therefore, examining the relationship between the relevant parameters is important in the rehabilitation process. In this context, the aim of the study is to examine the relationship between body awareness and pain, central sensitisation, disability and proprioception in patients with chronic non-specific neck pain.

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Key information

Conditions

Neck Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Karabuk University

Karabük, 78050, Turkey (Türkiye)

About this study

Chronic neck pain is a common pain problem related to the musculoskeletal system and can lead to permanent (chronic) disability over time. In approximately 50-85% of individuals with neck pain, complaints do not completely improve despite treatment, causing the pain to become chronic. Individuals with chronic neck pain have difficulty performing various activities in their daily lives, and this negatively affects their quality of life. Proprioceptive feedback in the neck region, that is, sensory information that allows the body to perceive its position in space, is very important for proper control of head and neck movements. However, chronic pain can lead to a condition called central sensitization. In this case, the individual's pain threshold decreases and they become more sensitive to stimuli that would normally not cause pain. This increased sensitivity can make it difficult for the brain to process proprioceptive information correctly, which can lead to impairments in body and neck awareness. Therefore, investigating the relationship between body awareness and pain level, central sensitization, disability status and proprioception in individuals with chronic non-specific neck pain is of great importance in terms of developing an effective rehabilitation program.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being between the ages of 18-65
  • Being diagnosed with chronic non-specific neck pain by a doctor
  • Being willing to participate in the study

Exclusion criteria

  • Having psychological disorders, mental disorders, cancer and severe depression
  • Having a history of traumatic injury
  • Having a history of primary or metastatic spinal malignancy, spinal fracture
  • Having a neurological disease (Hemiplegia, Multiple Sclerosis, Parkinson's, etc.)
  • Having been diagnosed with advanced osteoporosis
  • Having a history of surgical intervention or acute infection in the cervical region

Treatment and study plan

Primary outcomes

  1. Central sensitization

    Time frame: Baseline

    It will be evaluated with the "Central Sensitization Scale". The scale is scored between 0-100 and 40 points and above is recorded as sensitive.

  2. Pain severity

    Time frame: Baseline

    Pain intensity will be assessed with the Numerical Pain Scale. It is scored between 0-10 and the higher the score, the greater the pain intensity.

  3. Pain threshold

    Time frame: Baseline

    Pain threshold will be assessed with an algometer. An increase in the applied pressure indicates a higher pain threshold.

  4. Neck disability

    Time frame: Baseline

    Neck disability will be evaluated with the index. It varies between 0-50 points and the higher the score, the higher the disability.

  5. Proprioception

    Time frame: Baseline

    Proprioception will be recorded as the degree of deviation with the CROM device. As the degree of deviation increases, proprioception worsens.

  6. Body awareness

    Time frame: Baseline

    Body Awareness Questionnaire (BAF) will be used. It varies between 18-126 points and as the score decreases, awareness decreases.

  7. Neck awareness

    Time frame: Baseline

    It will be assessed with the Fremantle Neck Awareness Questionnaire. It varies between 0-36 and as the score increases, awareness decreases.

Sponsors and collaborators

Lead sponsor

Karabuk University

Other

Registry information

Official study title

Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 16, 2025
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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