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OpenTrials
Completed

NCT Number: NCT02984358

Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health

Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30

Exclusion criteria

  • On medication (except contraception)
  • Smokers
  • Diagnosed with any metabolic or cardiovascular conditions
  • BMI < 18 or > 30
  • Dietary restrictions (vegetarians/vegans, etc.)

Treatment and study plan

Animal protein based diet

Other

Low-nucleotide mycoprotein based diet

Other

High-nucleotide mycoprotein based diet

Other

Primary outcomes

  1. Serum uric acid concentrations

    Time frame: Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)

Secondary outcomes

  1. Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test)

    Time frame: Measured at baseline and after 1 week intervention (day 8)

  2. IL-6

    Time frame: Measured at baseline and after 1 week intervention (day 8)

  3. 24 h blood glucose homeostasis - measured using a Dexcom CGMS

    Time frame: Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7)

  4. Metabolomics (using Nuclear Magnetic Resonance - NMR)

    Time frame: Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

Effect of Chronic Mycoprotein Consumption, and of Its Nucleotide Content, in Uric Acid Concentrations and Other Markers of Metabolic Health in Adults

Acronym: MYTH

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Dec 6, 2016
Registry last updated
Jun 15, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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