Chronic Hepatitis C and Insulin Resistance

Chronic hepatitis C (CHC) is among the commonest chronic infectious disease in Australia with >200,000 exposed persons. Amongst non-infectious chronic conditions- Type 2 diabetes, obesity and heart disease are extremely common. This study will examine the relationship between insulin resistance, fat deposition in the liver, muscle and abdomen, and liver injury due to CHC

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Key information

Conditions

Hepatitis C Blood-Borne Infections Communicable Diseases Digestive System Diseases Fatty Liver Flaviviridae Infections Glucose Metabolism Disorders Hepatitis Hepatitis, Viral, Human Hyperinsulinism Infections Insulin Resistance Liver Diseases Metabolic Diseases Nutritional and Metabolic Diseases RNA Virus Infections Virus Diseases

Age range

25 year–55 year

Sex eligibility

Male

Study type

Observational

Primary location

Garvan Institute Of Medical Research, Sydney, New South Wales, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Caucasian male
Age: 25-55 years
Chronic Hepatitis C (PCR positive) and fibrosis ≤ F2 (if liver biopsy done)
Genotypes 1 or 3
Due to commence antiviral therapy
BMI < 30

Exclusion criteria

Cirrhosis or F3 fibrosis on liver biopsy (if done)
> 20 g ETOH per day
Type 2 Diabetes (need an OGTT if fasting BGL> 5.7)
Concurrent HIV
Other cause of liver disease

Treatment and study plan

Primary outcomes

Insulin Resistance by euglycaemic hyperinsulinaemic clamp Liver fat, abdominal fat and muscle fat measures

Time frame: 2 years

Secondary outcomes

insulin resistance post treatment of Hep C

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Garvan Institute of Medical Research

Other

Registry information

Official study title

Understanding the Relationship Between Insulin Resistance and Chronic Hepatitis C Infection

Important dates

Study start: 2006
Primary completion: 2008
Study completion: 2008
First posted: Jul 1, 2008
Registry last updated: Jul 14, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed