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OpenTrials
Completed

NCT Number: NCT01762098

Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization

Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic. Sometimes, patient with chronic endometritis can have genital bleeding, pelvic chronic pain, pain during sexual relations, persistent vaginal white loosing. The hysteroscopy can detect the presence or absence of chronic endometritis.

Some studies showed that the endometritis could have an impact on the embryo implantation and could explain recurrent miscarriages or repeated embryo implantation failures.

The goal of this study is to evaluate the frequency of the chronic endometritis in patients with recurrent miscarriages or repeated embryo implantation failures

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Key information

Conditions

Infertility Abortion, Spontaneous Adnexal Diseases Endometritis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Pelvic Inflammatory Disease Pregnancy Complications Urogenital Diseases Uterine Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Clinique Ovo

Montreal, Quebec, H4P 2S4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group repeated miscarriages

  • Women aged 18 to 43 years
  • ≥ 2 miscarriages before 14 weeks of gestation
  • Genetic (karyotype x2), thrombophilic and endocrine assessment should be completed

Group of implantation failure in In-vitro fertilization

  • Women aged 18 to 45 years
  • Absence of pregnancy after 3 good quality embryos transferred in women under 35 years and 4 embryos in the 35 years and over.

Exclusion criteria

  • Positive pregnancy test
  • Unexplained bleeding
  • Incomplete miscarriage assessment
  • Uterine malformation
  • Antibiotic treatment during or within one month prior to the biopsy

Treatment and study plan

Primary outcomes

  1. Rate of chronic endometritis

    Time frame: 1 day

Secondary outcomes

  1. Pregnancy rate

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Clinique Ovo

Industry

Registry information

Official study title

Prevalence of Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization

Important dates

Study start
2012
Primary completion
2014
Study completion
2015
First posted
Jan 7, 2013
Registry last updated
Jul 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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